The interaction type is modified from CTD
(modified using bold and italic)


def: The abundance of a chemical (if chemical synthesis is not known).
e.g., "CYP27B1 protein affects the abundance of Calcitriol"

An elemental function of a molecule.

genetic variation that gives rise to differing response to drugs

A molecular interaction.
Involving the use of two or more chemicals simultaneously.
The expression of a gene product.
The bending and positioning of a molecule to achieve conformational integrity.
Part of the cell where a molecule resides.
metabolic processing
The biochemical alteration of a molecule's structure (does not include changes in expression, stability, folding, localization, splicing, or transport).
— acetylation
The addition of an acetyl group.
— acylation
The addition of an acyl group.
— alkylation
The addition of an alkyl group.
— amination
The addition of an amine group.
— carbamoylation
The addition of a carbamoyl group.
— carboxylation
The addition of a carboxyl group.
— chemical synthesis
A biochemical event resulting in a new chemical product.
— degradation
Catabolism or breakdown.
— cleavage
The processing or splitting of a molecule, not necessarily leading to the destruction of the molecule.
— hydrolysis
The splitting of a molecule via the specific use of water.
— ethylation
The addition of an ethyl group.
— glutathionylation
The addition of a glutathione group.
— glycation
The non-enzymatic addition of a sugar.
— glycosylation
The addition of a sugar group.
— glucuronidation
The addition of a sugar group to form a glucuronide, typically part of an inactivating or detoxifying reaction.
— N-linked glycosylation
The addition of a sugar group to an amide nitrogen.
— O-linked glycosylation
The addition of a sugar group to a hydroxyl group.
— hydroxylation
The addition of a hydroxy group.
— lipidation
The addition of a lipid group.
— farnesylation
The addition of a farnesyl group.
— geranoylation
The addition of a geranoyl group.
— myristoylation
The addition of a myristoyl group.
— palmitoylation
The addition of a palmitoyl group.
— prenylation
The addition of a prenyl group.
— methylation
The addition of a methyl group.
— nitrosation
The addition of a nitroso or nitrosyl group.
— nucleotidylation
The addition of a nucleotidyl group.
— oxidation
The loss of electrons.
— phosphorylation
The addition of a phosphate group.
— reduction
The gain of electrons.
— ribosylation
The addition of a ribosyl group.
— ADP-ribosylation
The addition of a ADP-ribosyl group.
— sulfation
The addition of a sulfate group.
— sumoylation
The addition of a SUMO group.
— ubiquitination
The addition of an ubiquitin group.
The genetic alteration of a gene product.
Any general biochemical or molecular event.
response to chemical
Chemical resistance or chemical sensitivity.
The removal of introns to generate mRNA.
Overall molecular integrity.
The movement of a molecule into or out of a cell.
— secretion
The movement of a molecule out of a cell (by less specific means than export).
— export
The movement of a molecule out of a cell (by more specific means than secretion).
— uptake
The movement of a molecule into a cell (by less specific means than import).
— import
The movement of a molecule into a cell (by more specific means than uptake).